Nicole Kidman is set to play a post-op transsexual married to Charlize Theron in The Danish Girl. The Danish Girl is an indie filmed based on the true story of Danish artists Einar and Greta Wegener.
From the Hollywood Reporter (about the film): "Their marriage took a sharp left turn after Einar (Kidman) stood in for a female model that Greta (Theron) was set to paint. When their portraits become wildly popular in 1920s Copenhagen, Greta encouraged her husband to adopt the female guise. What began as a harmless game led Einer to a metamorphosis and landmark 1931 operation that shocked the world and threatened their love."
These characters don't sound too far off from what these girls are used to playing. Sounds really interesting, can't wait to hear more as it develops.